Open AccessRapid supercritical fluid chromatography analysis for 18 phthalate esters and bisphenol A in dairy products
Author(s) -
Yue Qiu,
Zhining Xia,
Genrong Li,
Q. Yu,
Jingyi Lu,
Yanfei Li
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/592/1/012015
Subject(s) - phthalate , chromatography , chemistry , bisphenol a , acetonitrile , detection limit , supercritical fluid , supercritical fluid chromatography , relative standard deviation , solvent , high performance liquid chromatography , organic chemistry , epoxy
A rapid and environmental method based on supercritical fluid chromatography (SFC) was established for the simultaneous analysis of 18 phthalate esters (PAEs) and bisphenol A (BPA) in dairy products. The stationary phases, organic modifiers, back pressures and column temperatures were investigated for the optimal separation. The BEH chromatographic column (100 mm x 3.0 mm, 1.7 mm) with sub-2-micron particles was performed for the detection of target compounds. 18 PAEs and BPA can be effectively separated within 5.5 min with acetonitrile as solvent modifier at the optimal conditions. The correlation coefficients (R 2 ) of 18 PAEs and BPA were more than 0.997 in the linear range of 0.3-10.0 mg/L, except for BMPP, DNOP and BPA in the range of 0.6-10.0 mg/L. The limits of quantification (LOQs) for PAEs and BPA were 0.15-0.60 mg/kg. The spiked recoveries and relative standard deviation (RSDs) were in the range of 88.2-120.5% and 1.55-13.51% for powdered milk infant formula samples, 89.6-114.2% and 0.69-10.06% for milk drinks samples, respectively. The SFC method can be used as a simple and efficient alternative route for the detection of 18 PAEs and BPA in dairy products.