Open AccessOptimatitation of mole ratio for synthesis reaction of Ketoprofen Eugenol Ester
Author(s) -
Adi Yugatama,
Agus Ramelan,
Elisa Novitasari
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/578/1/012056
Subject(s) - ketoprofen , eugenol , chemistry , absorbance , high performance liquid chromatography , yield (engineering) , fourier transform infrared spectroscopy , nuclear chemistry , chromatography , organic chemistry , materials science , physics , quantum mechanics , metallurgy
Ketoprofen is a NSAID which often used, but has been shown to induce gastrointestinal irritation. The side-effect arises because of the presence of carboxylic acid groups. The carboxylic acid groups can be changed by estherification reaction between ketoprofen and eugenol using an acid catalyst. This study was purposed to find out the effect of mole ratio of ketoprofen : eugenol on the synthesis Ketoprofen Eugenol Ester (KEE). The mole ratio of ketoprofen : eugenol which used in the study were 1:3; 1:4; 1:5; 1:6; 1:7; 1:8. The synthesis was done by heating up ketoprofen, eugenol, and HCl as the catalyst. The results of synthesis were characterized using TLC, FTIR, UV-Vis Spectrophotometer, and HPLC. Then, the data was analyzed statistically using One Way ANOVA (SPSS). The result of sample analysis using TLC showed the Rf value ±0.07. The FTIR analysis indicated that there were peak C=O ester and C-O ester. The highest yield value, absorbance of UV-Vis spectrophotometer and peak area of HPLC were found in the mole ratio 1:6. The One-Way ANOVA statistical analysis indicated that there was a significant difference between the variations of mole ratio which were used.