Open AccessOptimation Formula of SNEDDS Dosage from Ethanol Extract of Turmeric (Curcuma domestica) With Waste Oil of Eel (Anguilla spp.) as A Carrier
Author(s) -
Nining Rahayu,
Agung Budiharjo,
Artini Pangastuti,
Anif Nur Artanti,
Fea Prihapsara,
Marti Harini
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/578/1/012049
Subject(s) - chemistry , curcuma , oleic acid , chromatography , bioavailability , solubility , pulmonary surfactant , maceration (sewage) , food science , ethanol , traditional medicine , biochemistry , biology , pharmacology , environmental science , medicine , organic chemistry , environmental engineering
Turmeric have a lot of advantages for us, usually for treatment a lot of desease, and it has efficiency as a drug. But turmeric extract have very low solubility and it cause minimal oral bioavailability. While nutrition of waste oil of Eel ( Anguilla spp .) are higher than the other fish, because this waste oil have palmitic acid, linoleic acid, and oleic acid that usefull for treatment some disease. So, in this research, turmeric extract made by Self-Nanoemulsifying Drug Delivery System (SNEDDS) method with waste oil of Eel ( Anguilla spp .) as a carrier to overcome solubility of turmeric extract. In this research, the turmeric was extracted with maceration method using ethanol as a solvent. This extracting showed high average rendemens are 6.62-8.19 %. Percentages of curcumin for this turmeric extract was calculated by TLC-densitometry, shows 2.99 % b/b. This extract had the optimization of the formulation of the composition of surfactant by Tween 80, cosurfactant by PEG 400, and waste oil of Eel ( Anguilla spp .) as a oil carrier. After done some tests, include loading dose test on the selected optimal formulation, then we had determine that quality. It included by counting emulsification time, observations of the particle size, its distribution, and zeta potential of nanoemulsi using PSA. The results of SNEDDS optimal dosage was calculated by Design Expert 7 had a mass (gram) ratio of waste oil of Eel ( Anguilla spp. ):Tween 80 (surfactant): PEG 400 (cosurfactant) = 0.55 :4.10:0.35 added with loading dose 0.5 g of Turmeric extract in 5 g system of SNEDDS. The result had a transmittance value of 91.48-92.17 % with emulsification time less than 30 seconds and it classified type A (Sakhti et al , 2013). Particle size of the chosen SNEDDS nanoemulsion turmeric extract that calculated by PSA, shows 11.9 nm and with polydispersity index are 0.118 droplet and zeta potential of -11.8 mV.