Open AccessSynthesis and Characterization of Some Bromochalcones Derivatives
Author(s) -
V H Elfi Susanti,
Widiastuti Agustina Eko Setyowati
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/578/1/012002
Subject(s) - mass spectrum , chemistry , mass spectrometry , condensation , characterization (materials science) , base (topology) , claisen condensation , organic chemistry , grinding , combinatorial chemistry , catalysis , chromatography , materials science , nanotechnology , mathematics , thermodynamics , composite material , mathematical analysis , physics
Chalcones are considered to be precursors of flavonoids and have variety of biological activities. Three of bromochalcones derivatives were synthesized by a green chemistry approach using grinding technique and their structure also confirmed. Synthesis of bromochalcone, 4′-bromo-4-methoxychalcone, 4′-bromo-3, 4-dimethoxychalcone, 4′-bromo-3, 4, 5-trimethoxychalcone were carried out using starting material of 4-bromoacetophenone through Claisen-Schmidt base catalyzed condensation. The structures of the synthesized compounds were confirmed by gas chromatography–mass spectrometry (GC-MS). The mass spectra of the compounds were showed corresponding molecular ion peak which was correlated with their molecular weight of that respected compound (4′-bromo-4-methoxychalcone = 317, 4′-bromo-3, 4-dimethoxychalcone = 347, 4′-bromo-3, 4, 5-trimethoxychalcone = 377).