Open AccessSpectrophotometric Estamation of Meloxicam Using Charge Transfer Complex
Author(s) -
Abdulbari Mahdi Mahood,
Nahawnd H. Najm
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/571/1/012081
Subject(s) - meloxicam , detection limit , absorbance , chemistry , ferric , ferrous , accuracy and precision , analytical chemistry (journal) , correlation coefficient , chromatography , cyanide , mathematics , inorganic chemistry , statistics , medicine , organic chemistry , pharmacology
In this study we developed cheap and precise analytic method to measure Meloxicam concentration in bulk and pharmaceutical formula. The method based on the reaction between ferric ion and Meloxicam to yield ferrous ion. Then the former ion Fe 2+ reacted coupled with potassium ferric cyanide to forming colored compound has a maximum absorbance at 708 nm. The method was validated by calculating the precision and accuracy. The method follows Beer-Lamber law at a range of (0.1-11) μg/mL with correlation coefficient is 0.9978. Accuracy and precision of the proposed method were estimated and shown average of recoveries between (98.7-99.5 %) with precision represented by RSD% equal to 0.56. We also calculated the detection limit (LOD) and quantitative of limit (LOQ) were 0.0092 μg/mL 0.030 μg/mL respectively The modified suggested method was used to measure Meloxicam in pharmaceutical preparation without additives interference and shows a good agreement with the standard method. Therefore, it can be used for routine works for quality control for estimation of the Meloxicam in bulk and pharmaceutical preparation as tablets.