Open AccessSynthesis of Novel Isochromen-1-one analogues of Etodolac
Author(s) -
Ayyakannu Arumugam Napoleon,
Vijay Sharma,
Kadirappa Aggile
Publication year - 2017
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/263/2/022021
Subject(s) - etodolac , thio , chemistry , stereochemistry , nuclear magnetic resonance spectroscopy , mass spectrometry , combinatorial chemistry , chromatography , biochemistry
In the present work, anti-inflammatory drug based novel isochromen-1-one, their thio and N -methylated analogues were synthesized from the etodolac bulk drug, 1 . All the synthesized compounds were purified and successfully characterized by FT-IR, 1 H NMR, 13 C NMR and Mass spectroscopy. All the derivatives procured are with remarkable yields from 67-72%.