Open AccessStudy of the utility of Fe2O3-Au nanocomposite in photodynamic therapy
Author(s) -
Divya Rajan,
Frincy Francis,
Daniya Thomas,
Meenakshi Ramankutty,
Santhi Ani Joseph
Publication year - 2022
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/1233/1/012005
Subject(s) - trisodium citrate , chloroauric acid , nanocomposite , viability assay , nuclear chemistry , materials science , irradiation , oxide , colloidal gold , iron oxide , nanoparticle , nanotechnology , chemical engineering , chemistry , in vitro , metallurgy , biochemistry , physics , nuclear physics , engineering
A novel multifunctional nanofluid composite of Iron oxide/Gold (Fe 2 O 3 -Au) was prepared using simple wet chemical method by reducing Chloroauric acid using trisodium citrate in the presence of Fe 2 O 3 stock solution. The optical and morphological characterization confirmed the formation of hybrid structure of Iron Oxide with Gold nanoparticles. In-vitro cytoprotective studies of the sample was carried out in L929 cells. The study showed an increase up to 15% in the cell viability by the co-administration of 25 μL of Fe 2 O 3 -Au nanofluid in the L929 cells, which suffered significant reduction in cell viability due to laser irradiation. Thus, the sample is found to possess potential application in Photodynamic therapy.