Open AccessProbe into DNA interaction, cell toxicity and antifungal activities of phyto-synthesized yttrium oxide (Y2O3) nanoparticles
Author(s) -
Rugmani Meenambal,
Senthilnayagam Hema,
Vedika Tomar,
Anita Puyam
Publication year - 2022
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/1225/1/012044
Subject(s) - nuclear chemistry , fourier transform infrared spectroscopy , yttrium , agarose gel electrophoresis , exserohilum , nanoparticle , toxicity , chemistry , agarose , antifungal , materials science , oxide , dna , nanotechnology , biochemistry , biology , organic chemistry , botany , microbiology and biotechnology , blight , chemical engineering , engineering
Green synthesis is considered to be eco-friendly approach in comparison to chemical mediated synthesis and hence the study demonstrates facile Nyctanthes arbortristis mediated phyto-synthesis of biocompatible yttrium oxide (Y 2 O 3 ) nanoparticles. X-ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) were employed to confirm the formation of cubic Y 2 O 3 nanoparticles. Further, the interaction of Y 2 O 3 with calf thymus-DNA were scrutinized by UV-visible, fluorescence spectroscopy and agarose gel electrophoresis techniques and the results suggested the stabilization of CT-DNA by the biosynthesized Y 2 O 3 . Also, the synthesized Y 2 O 3 does not exhibit any toxicity in SK-MEL, human melanoma cell lines. Further, the studies on antifungal activities of Y 2 O 3 nanoparticles revealed significant inhibitory effects on the growth of plant pathogen Exserohilum rostratum causing Exserohilum leaf blight in pearl millet. Hence, the findings deliver the foundation for furtherbiological research investigations of Y 2 O 3 and its application in phytopathogen control.