Open Access131I radioactive self-expandable metallic stents for the therapy of malignant biliary obstruction
Author(s) -
Meirong Liu,
Mengfei Hou,
Qinghe Wu,
Chunfu Zhang
Publication year - 2021
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/1133/1/012002
Subject(s) - stent , restenosis , medicine , brachytherapy , bile duct , nuclear medicine , biliary tract , radiology , biliary stent , radiation therapy , surgery
Biliary stent implantation has become a standard approach for patients with unresectable malignant biliary obstruction. Unfortunately, in-stent restenosis after stent implantation still occurs because of tumor overgrowth. The majority of studies show that radioactive stents harbor both the obstructed biliary tract-dilating and tumor-suppressing functions. In this study, we designed a kind of novel 131 I-labeled radioactive self-expandable metallic stent (SEMS) that combines the mechanical dilation forces induced by stent expansion and 131 I intraluminal brachytherapy, which was prepared by first coating the SEMS with poly (diallyl acrylate) (PDA) and then labeling with iodine-131. The designed stents would not only have a longer patency time but also is able to inhibit biliary compression caused by tumor growth. The PDA coating was robust and flexible. The 131 I labeling rate was about 60%, and after a 16-day test of radiochemical stability of 131 I, the radioactive stability was around 80%. In addition, the radiochemical stability of 131 I could be improved by PDA recoating post- 131 I labeling. In conclusion, we designed and fabricated a kind of novel 131 I-labeled radioactive self-expandable metal stents by labeling 131 I on the PDA-coated stent. We provide a new idea of radioactive stents design, which would extend the patency time of the stent while reducing the rate of stent restenosis after implantation.