Open AccessFabrication of Bio-Scaffold by Additive manufacturing technique for Bone Synthesis using Generative Design
Author(s) -
S Renold Elsen,
T Mahendran,
Piyush P Atkare,
Amit A Bhosale
Publication year - 2021
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/1123/1/012068
Subject(s) - scaffold , biomedical engineering , computer science , tissue engineering , regeneration (biology) , fabrication , rapid prototyping , engineering design process , 3d printing , materials science , engineering , mechanical engineering , medicine , biology , alternative medicine , pathology , microbiology and biotechnology
In tissue engineering, the main objective is the regeneration of damaged tissues and organs which is caused due to diseases, injuries, and inherited medical conditions. Today with the help of tissue engineering, damaged tissues and organs can be repaired with the use of artificially made structures for support, often called the scaffold. To construct a 3D structure, materials with special properties such as bioresorsablity and biocompatibility are used. This 3D structure is similar to the area of tissue implant to recover injury and regeneration of tissue. The porosity of the matrix should be maintained to promote the differentiation of cells at the control rate. Generative design is an iterative process that includes a Machine-learning program that creates a definite number of design outputs for the given loads and boundary conditions by the designer. The main objective of generative design is to increase the stiffness and to reduce the mass keeping the strength constant. In this Generative design has been used to get the optimum results using Polylactic Acid (PLA). The model of scaffold is based on the injury in femur bone thus the forces acting on the Juvenile hip joint in a one-legged stance are considered. In the last decade, intensive research had been carried out for the development of scaffold with the use of bio fabrication methods to reduce the time of manufacturing, increase precision, and decrease the cost of production.