Open AccessResults of long-term permeability of small-diameter vascular prostheses modified by pro-angiogenic factors and athrombogenic drug coating (model of large laboratory animals)
Author(s) -
Е. О. Кривкина,
А. В. Миронов,
А. Р. Шабаев,
М. А. Резвова,
Е. А. Великанова,
В. О. Ткаченко,
M. Yu. Khanova,
T. Yu. Sergeeva,
Sergei S Krutitskiy,
Л. В. Антонова
Publication year - 2021
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/1093/1/012017
Subject(s) - biocompatibility , biomedical engineering , polyhydroxybutyrate , coating , medicine , polycaprolactone , permeability (electromagnetism) , vascular permeability , materials science , chemistry , pathology , nanotechnology , composite material , polymer , biology , metallurgy , biochemistry , membrane , bacteria , genetics
Developed for bypass surgery, tissue-engineered vascular grafts should remain passable after implantation and have high rate of endothelialization to ensure long-term patency, atrombogenicity and biocompatibility. This study was aimed at assessing the long-term patency of polyhydroxybutyrate/valerate (PHBV)/polycaprolactone (PCL) vascular grafts modified by pro-angiogenic factors and athrombogenic drug coating in a large laboratory animal model.