Open AccessModified Fluorescent PEG-Based Carrier System for In-vitro Imaging
Author(s) -
Aswathi Thomas,
Aravind Kumar Rengan
Publication year - 2021
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/1091/1/012020
Subject(s) - ascorbic acid , polyethylene glycol , fluorescence , peg ratio , in vitro , biocompatible material , chemistry , polymer , coating , yield (engineering) , nanotechnology , materials science , organic chemistry , biochemistry , biomedical engineering , medicine , physics , food science , economics , metallurgy , finance , quantum mechanics
A facile, one-pot synthesis of polymer based fluorescent coating agent was developed. Polyethylene glycol (PEG), known to be biocompatible and biodegradable, has been modified with ascorbic acid (AA) to yield modified fluorescent PEG based carrier system (PEGAA). The fluorescence obtained was tuned using varying concentrations of ascorbic acid. With increasing concentration of ascorbic acid, a red shift in fluorescence was observed which could be utilized for effective in vitro imaging. The cellular uptake studies reveal the potential use of this novel material for bioimaging applications.