Open AccessSpectrophotometric Determination of Mefenamic acid using Metol reagent by Oxidative Coupling Reaction
Author(s) -
Istabraq Qahtan Rashad,
Mohsin Hamza Bakir
Publication year - 2021
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/1058/1/012081
Subject(s) - mefenamic acid , oxidizing agent , chemistry , reagent , molar absorptivity , potassium periodate , chromatography , oxidative coupling of methane , nuclear chemistry , absorption (acoustics) , spectrophotometry , organic chemistry , detection limit , materials science , catalysis , physics , optics , composite material
A simple, sensitive, and accurate spectrophotometric method for the determination of Mefenamic acid is described. The method is oxidative coupling reaction of Mefenamic acid with metol using potassium periodate as an oxidizing agent in alkaline medium to form a water-soluble product, that is stable and has a maximum absorption at 533 nm. Beer’s law is obeyed in a concentration range of 2.4-24 μg/ml Mefenamic acid with a molar absorptivity of 7.2x103 L/mol.cm. The proposed method has been successfully applied to the determination of Mefenamic acid in various pharmaceutical preparations.