Open AccessSpectrophotometric Determination of Naproxen using Metol reagent by Oxidative Coupling Reaction
Author(s) -
Ghania Abed Hasan,
Mohsin Hamza Bakir
Publication year - 2021
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/1058/1/012079
Subject(s) - molar absorptivity , naproxen , absorbance , chemistry , reagent , detection limit , chromatography , correlation coefficient , oxidative coupling of methane , spectrophotometry , analytical chemistry (journal) , organic chemistry , mathematics , medicine , alternative medicine , pathology , physics , statistics , methane , optics
A new and simple spectrophotometric method was used for the determination naproxen by oxidative coupling with metol the presence of N –Bromosuccinimide in acid medium, Absorbance of the obtained colored products was measured at the corresponding optimum wavelengths 535 nm, Beer’s law is obeyed over the concentration of 0.8-17.6 μg/ml, and The molar absorptivity of 9.07×10 3 L/mole.cm, Sandal’s sensitivity index of 0.02538 μg.cm-2. The detection limits were 0.1730 μg/ml and the quantitative limit 0.5768/ml, the correlation coefficient of 0.9981and recovery range from 100.21 – 98.27%. The method was successful to determine naproxen in drug tablets formulation.