Open AccessComplex formation of copper(II), nickel(II) and γ-L-glutamyl-L-cysteinyl-glycine (GSH)
Author(s) -
Anpoli
Publication year - 2021
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/1048/1/012006
Subject(s) - nickel , chemistry , copper , glutathione , metal , redox , glycine , inorganic chemistry , stereochemistry , medicinal chemistry , organic chemistry , enzyme , biochemistry , amino acid
The formation of Cu(II) and Ni(II) complexes of GSH in conditions of 2-fold GSH excess over Ni(II) was studied by MALDI MS and MS/MS. The instrumental data demonstrated that S and N of GSH are involved in the coordination metal spheres, while COOH did not participate to complexation. NiL 2 is a square-planar Ni(II) specie able to form one electron redox couple with Ni-(III) complex. It was found to dimerize rapidly via disulphide bond formation in the presence of air.