Open AccessSynthesis, characterization, and activity of 6-(10H-phenothiazine-10-yl)-1H,3H-benzo[de]-isochromen-1,3-dione derivative of 4-aminophenylacetic acid
Author(s) -
Temenuzhka Haralanova,
Marin Marinov,
Iliana Kostova,
I. Nikolova,
Stanka Damyanova,
Neyko Stoyanov
Publication year - 2021
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/1031/1/012111
Subject(s) - phenothiazine , chemistry , derivative (finance) , bacteria , corpus albicans , minimum inhibitory concentration , antibacterial activity , yeast , escherichia coli , candida albicans , bacillus subtilis , stereochemistry , microbiology and biotechnology , antimicrobial , organic chemistry , biochemistry , biology , genetics , gene , financial economics , economics , pharmacology
The objective of the present paper was to study the synthesis of a new compound 6-(10 H -phenothiazme-10-yl)-1 H ,3 H -benzo[de]-isochromen-1,3-dione derivative of 4-aminophenylacetic acid (PTZD). Its physicochemical characteristics and spectral data were presented. PTZD was found to have good inhibitory activity. The phenothiazine derivative showed good fungicidal activity against the studied yeast ( S. cerevisiae and C. albicans ) and mold species ( A. brasiliensis and F. moniliforme) , weak bactericidal activity against the Gram-positive bacteria S. aureus and B. subtilis and did not affect the growth of Gram-negative bacteria E. coli, P. aeruginosa and S. abony.