Open AccessAction model of Angiotensin II receptors on smooth muscle ileum preparations
Author(s) -
Miroslav Vasilev,
Kaloyan Yankov
Publication year - 2021
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/1031/1/012069
Subject(s) - angiotensin ii receptor type 1 , angiotensin ii , ileum , receptor , medicine , endocrinology , chemistry , angiotensin receptor , smooth muscle , antagonist , biology
This paper presents an approach using control theory methods to monitor the effect of Angiotensin II (Ang II), AT1 and AT2 receptor subtypes on the visceral smooth muscle in ileum preparations. Since AT1 and AT2 are involved in feedback during the regulatory action of Ang II, it is convenient to block them with a suitable antagonist. In this way, three transients were obtained, which were identified by a second-order differential equation. The individual identification vector was calculated for each of the processes. The analysis of the models showed that when the PD 123319 blocker was applied, the amplitude of the responses to smooth muscle contractions increased. From this, it can be concluded that the AT2 type receptors have an AT1 antagonistic effect during the contractile process.