Open AccessAntioxidant compound from Myristica fatua Houtt Leaves
Author(s) -
Sofa Fajriah,
Melia Megawati,
Ahmad Darmawan,
Sumi Hudiyono,
Soleh Kosela,
Muhammad Hanafi
Publication year - 2021
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/1011/1/012035
Subject(s) - antioxidant , dpph , chemistry , methanol , fractionation , traditional medicine , organic chemistry , medicine
Antioxidant plays an important role in reducing the risk of chronic diseases. By using DPPH radical scavenging assay-guided fractionation, a bioactive compound has been isolated from the methanol extract of the leaves of Myristica fatua Houtt and subsequently identified as methyl 3,4-dihydroxybenzoic (MDB). The structure of MDB was confirmed by UV, FT-IR, MS, 1- and 2-D NMR spectroscopy. This compound exhibit antioxidant activity together with previous compounds i.e (7S,8R,8′S,7′S)-7,7′-bis(3-hydroxy-5-methoxyphenyl)-8,8′-dimethylbuthane-7,7′-diol and 3”-hydroxy demethyldactyloidin with IC 50 values 7.96, 101.1 and 15.4 μg/mL, respectively. These findings demonstrate that MDB can be considered as a natural antioxidant.