Open AccessInhibition of the α-glucosidase enzyme from Pelawan stem extract (Tristaniopsis merguensis Griff)
Author(s) -
Robby Gus Mahardika,
Gama Kusuma,
Occa Roanisca,
Henri
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/926/1/012001
Subject(s) - flavonoid , diabetes mellitus , polyphenol , traditional medicine , chemistry , methanol , enzyme , insulin , food science , pharmacology , medicine , biochemistry , antioxidant , organic chemistry , endocrinology
Diabetes mellitus continues to increase along with the increasing pattern of consuming ready-to-eat foods. The consequences of this habit will have a negative impact on the health of the body so that it can cause death. Treatment of diabetes mellitus is carried out in various ways, including administration of insulin and synthetic drug therapy. However, this medication has dangerous side effects. Therefore, research was carried out on Pelawan stems (Tristaniopsis merguensis Griff) which have the potential to be associated with secondary metabolites and bioactivity as antidiabetic so that they can be considered as raw material for herbal medicines in the future. total phenolic content of the methanol fraction of T. merguensis stems is 176.37 mg GAE/g DW. The total flavonoid content of the methanol fraction of T. merguensis stems is 9.85 mg QE/g DW. The results of the antidiabetic test for the methanol fraction of T. merguensis stems obtained an IC50 of 5.31 μg/mL. When viewed from the qualitative results of phenolics and flavonoids that have been carried out, it is likely that the activity of the α-glucosidase enzyme in this study is more influenced by polyphenolic compounds.