Open AccessThe Therapeuticrole of Moringa Oleifera Against Bisphenol A toxicity That Induce Renal Effects in Rats
Author(s) -
Hind Mohammed Saleh,
Hani Sabbar Ayed,
Ahmed Ibrahim Salih
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/910/1/012084
Subject(s) - moringa , saline , kidney , medicine , traditional medicine , creatinine , urea , toxicity , oral administration , pharmacology , chemistry , biochemistry
The objective of the current work was to induce histological lesions by BPA(Bisphenol A)and then diagnosis the therapeutic role of Moringa oleifera. 66 adult male rats were used in the present work and divided as following: Rats were administrated (orally) normal saline as control group. Rats group were administrated (orally) 5mg BPA and divided into 4 subgroups were each subgroup treated with Moringa oleifera (100mg/kg, 200mg/kg, 300mg/kg and 400mg/kg), respectively. Rats were administrated (orally) 10mg BPA and divided to 4 subgroups were each subgroup treated with Moringa oleifera (100mg/kg, 200mg/kg, 300mg/kg and 400mg/kg), respectively. The findings of BPA groups showed significant (P<0.05) elevated in urea and creatinine with different histological lesions in the kidney include damaged glomerulus, degeneration of tubules cells, and lymphocytes infiltration. After treatment with Moringa oleifera, renal parameters and kidney tissues were back to the normal state and non-significant (P≤0.05) changes compared with the control group.