Open AccessEimeria piriformis live-attenuated vaccine is successfully lower clinical coccidiosis of rabbits raised in tropic
Author(s) -
Penny Humaidah Hamid,
Sigit Prastowo,
Widagdo Sri Nugroho,
Rini Widayanti
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/902/1/012037
Subject(s) - coccidiosis , antibiotics , eimeria , attenuated vaccine , medicine , livestock , animal husbandry , veterinary medicine , biology , microbiology and biotechnology , ecology , virulence , biochemistry , gene , agriculture
Livestock can sustain expected levels of productivity if the disease is controlled successfully. Rabbit coccidiosis is the major disease-causing high mortality and morbidity. Since no vaccine is available, the eradication is primarily based on careful management combined with medication in feed or water. Chemical coccidiostat is not only raising antibiotic resistance. It also adds environmental contamination since antibiotic is secreted onto land and water. In this report, we attenuate Eimeria piriformis and used it as the vaccine candidate for New Zealand rabbits in Yogyakarta, Indonesia. 90% of rabbits immunized with live attenuated E. piriformis showed no severe signs when challenged with wild type containing 5 x 10 5 oocyst. The use of live-attenuated E. piriformis is promising as coccidiosis prevention and control program. The strategy would reduce the continuous usage of chemoprophylactic substances in rabbit husbandry and therefore contribute in reducing environmental contamination of antibiotics