Open AccessPuupehenone, an Anticancer Produced by the Indonesian Marine Sponge Hyrtios sp.
Author(s) -
Viqqi Kurnianda,
Musri Musman
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/869/1/012050
Subject(s) - sponge , indonesian , bioassay , escherichia coli , biology , stereochemistry , botany , chemistry , biochemistry , ecology , gene , linguistics , philosophy
In a continuous study on the Indonesian marine sponges, we found a Hyrtios sponge during our expedition in Lhok Mata Ie, an isolated place around Aceh Besar, Indonesia in 2017. The bioassay-guided separation with several steps of chromatography was applied to give pure material. Moreover, the spectroscopic analysis revealed the presence of puupehenone ( 1 ), a unique class of merosesquiterpene together with its analogs ( 2 - 3 ). Their structures and bioactivity against multidrug-resistant Escherichia coli (MDR E. coli ) together with several cell lines are described here.