Open AccessSnail mucus suppresses anti dsDNA antibodies in lupus mice
Author(s) -
Arief Nurudhin,
Nurhasan Agung Prabowo,
Astutiningsih Trias Ramadhani
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/824/1/012058
Subject(s) - systemic lupus erythematosus , snail , mucus , antibody , lupus nephritis , immune system , medicine , immunology , pristane , endocrinology , gastroenterology , pharmacology , andrology , biology , chemistry , ecology , disease , hydrocarbon , organic chemistry
Lupus is closely related to weather changes. Changes in extreme weather due to climate changes can trigger lupus flares and cause death. Therefore, many studies are trying to find a drug that can cure lupus. Snail mucus has the properties of suppressing the immune system. The aim of this study is to see how snail mucus affects the levels of anti-dsDNA antibodies in lupus model mice. Experimental study uses a posttest-only group design. The control group was mice with 0.5 cc intraperitoneal (IP) saline. The lupus nephritis group was mice with pristane 0.5 cc IP, and the therapy group was mice with 0.5 cc IP pristane and 0.5 cc snail mucus per day at the 4th month of treatment for 14 days and after that the mice blood serum was taken and examined in the laboratory. The dsDNA antibody examination used the ELISA method. Statistical test with Anova followed by post hoc test. P is significant if it is less than 0.05. There was an increase in the levels of antibody dsDNA (p = 0.016) in the lupus group (75.13 + 22.5mg/dL) compare with the control group (56.96 ± 11.77 mg/dL), but there was a decrease in anti-dsDNA antibodies in the mice with snail mucus (56.01 ± 8.29 mg/dL; p = 0.02), and the methyl prednisolone group (53.47 ± 13.53 mg/dL; p = 0.009) when compared to the lupus group. Snail mucus suppresses anti dsDNA antibody levels in lupus mice.