Open AccessProperties of Hyaluronic Acid Nanoparticles Modified by Histidine for Embedding Flavonoids
Author(s) -
Peng Wang,
Li Guo,
Yunlei Chai,
Xue Ma
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/781/5/052028
Subject(s) - hyaluronic acid , conjugate , nanoparticle , chemistry , nuclear chemistry , drug delivery , transplacental , swelling , formamide , porosity , chemical engineering , materials science , organic chemistry , nanotechnology , mathematics , pregnancy , mathematical analysis , fetus , genetics , placenta , engineering , biology
Hyaluronic acid (HA) was modified by histidine (His) to prepare His-HA conjugate, and flavonoid-containing mixed nanoparticles were embedded by formamide and dimethylformamide with ultrasonic treatment. The porosity, swelling degree, encapsulation efficiency, drug loading and in vitro release of nanoparticles were measured for embedding capacity. The results showed that the prepared His-HA conjugate with ratio of 9:1 had a high buffering capacity at endosome pH 6.0, and the rate of encapsulation and drug loading for embedding effect were 50%∼80% and 8%∼13% respectively.