Open AccessThe Effect of 96% Ethanol Extract of Binahong Leaf on Hyperglycemia White Male Rats Using Total Cholesterol and Triglyceride Parameters
Author(s) -
Dwitiyanti,
Tera Rorenza
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/755/1/012005
Subject(s) - triglyceride , hyperlipidemia , atorvastatin , cholesterol , sucrose , simvastatin , ethanol , chemistry , total cholesterol , food science , medicine , biochemistry , diabetes mellitus , endocrinology
Hyperlipidemia is an increase in lipid levels such as cholesterol and triglycerides. Binahong leaves contain compounds that possess anti-hyperlipidemic properties. This study aims to determine the effect of 96% ethanol extract of binahong leaves on reducing cholesterol and triglyceride levels in hyperglycemic and hyperlipidemic rats. The testing animals were divided into 6 groups consisting of normal group, negative group (high fat and sucrose diets), positive group (atorvastatin), dose I group (12.5 mg / kg), dose II (25 mg / kg), and dose III (50 mg / kg). All groups, except the normal group, were induced with high fat and sucrose diets. The results obtained showed that the binahong leaves extract was effective in reducing cholesterol and triglyceride levels. The dose II group was comparable to the positive control in reducing cholesterol and triglyceride levels with the percentage reduction of 48.97% and 47.17%, respectively.