Open AccessThe Multiple Sequence Alignment and Evolutionary Analysis of Angiotensin-converting Enzyme 2 Diverse Species
Author(s) -
Kexin Sun
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/714/3/032013
Subject(s) - phylogenetic tree , biology , host (biology) , angiotensin converting enzyme 2 , peptide sequence , phylogenetics , evolutionary biology , covid-19 , troglodytes , virology , glycoprotein , zoology , genetics , gene , medicine , disease , infectious disease (medical specialty) , pathology
The sudden outbreak of new coronavirus (2019-nCoV) in Wuhan significantly influences in China, with wide attention attracted to investigate its origin, intermediate host, transmission pathway, and pathogenic mechanism. 2019-nCoV is very similar to SARS. They may use the similar receptor to recognize and attack host cell. Angiotensin-converting enzymes 2 (ACE2) is a main receptor of 2019-nCov and SARS, which interact with the surface spike glycoproteins (S proteins) of the coronaviruses. However, we still don’t know how the 2019-nCoV infected human and which species is the intermediate host. In this study we analyzed data of amino acid sequence of ACE2 and constructed phylogenetic tree. The phylogenetic tree showed ACE2 of human is highly similar to Pongo abelii and Pan troglodytes. Furthermore, our results suggest that Pongo abelii and Pan troglodytes may be another host and we must protect these animals from be infected. Our result is beneficial for a global pneumonia epidemic prevention.