Open AccessAntiaging effect of brown macroalgae Sargassum cristaefolium gel formulation by inhibition of collagen degradation
Author(s) -
Eka Sunarwidhi Prasedya,
Ni Wayan Riyani Martyasari,
Bq Tri Khairina Ilhami,
Hasriaton Padmi,
Sri Widyastuti,
Anggit Listyacahyani Sunarwidhi,
Haji Sunarpi
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/712/1/012030
Subject(s) - chemistry , sargassum , in vivo , ethanol , degradation (telecommunications) , chromatography , biochemistry , food science , botany , biology , microbiology and biotechnology , computer science , algae , telecommunications
Recent strategies for skin protection against UV radiation have included the incorporation of natural photoprotective agents, such as gel formulations. Our previous study demonstrated the UV photoprotective activity of brown macroalgae Sargassum cristaefolium ethanol extract (SCE). In this study, we aim to determine the optimum gel formulation for the incorporation of SCE. In addition, the UV antiaging activity was evaluated in vivo with mice as animal models. Gel formulation with various concentrations of Glycerin, Carbopol, and TEA was evaluated with the simple lattice design (SLD) method in Design-Expert Software. The optimum gel formula containing 0.1% SCE inhibited collagen degradation in mice skin irradiated by UV-A. It can be concluded that the gel formula successfully incorporates SCE and possibly provides antiaging activity in vivo by inhibition of collagen degradation. However, further investigations need to be done to conclude the photoprotective activity of SCE gel formulation (SCEg). In addition, exploration of the Sargassum brown macroalgae based gel formula should be considered for cosmeceutical applications.