Open AccessEffect of glycolide dosage on molecular weight of poly (lactic-co-glycolic acid)
Author(s) -
Xiaoqi Chen,
Lu Bai,
Jia Tian,
Haijun Zhou,
Mengmeng Zhou,
Jijun Xiao,
Yantao Li
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/692/3/032107
Subject(s) - plga , differential scanning calorimetry , glycolic acid , gel permeation chromatography , intrinsic viscosity , polymer chemistry , viscometer , polymer , ubbelohde viscometer , lactic acid , chemical engineering , permeation , lactide , materials science , polymerization , molar mass distribution , chemistry , viscosity , nuclear chemistry , organic chemistry , composite material , nanotechnology , membrane , biochemistry , nanoparticle , thermodynamics , bacteria , genetics , biology , engineering , physics
A series of biodegradable polymers, poly (lactic-co-glycolic acid) (PLGA) were prepared by ring-opening polymerization with racemic lactide and glycolide as main raw materials. Gel Permeation Chromatography (GPC), differential scanning calorimetry (DSC) and ubbelohde viscometer were uesd for the characterizations of the PLGA. And the effect of glycolide’s (GA) content on molecular weight (Mw), vitrification transition temperature (Tg), intrinsic viscosity [η] of PLGA was discussed. The results show that the GA’s content in PLGA molecular structure is higher than the actual feeding ratio. Meanwhile, with the increase of GA’s content, the Mw, [η] and Tg of PLGA decreased.