Open AccessThe dynamics of humoral immunity factors in rats under experimental BLV infection
Author(s) -
Е. С. Красникова,
Serguei Kozlov,
А.В. Красников,
A. S. Belyakova,
Р. В. Радионов
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/677/3/032114
Subject(s) - offspring , titer , humoral immunity , complement system , immunity , immunology , biology , complement (music) , properdin , immune system , antibody , pregnancy , biochemistry , genetics , complementation , gene , phenotype
Analysis of the dynamics of some the most indicative markers of humoral immunity of BLV -infected rats and their offspring are presented in the article. Despite the dynamics of markers in adult rats and their offspring is somewhat different, certain tendencies are revealed. It is shown that in infected rats the immunological reaction develops according to the principle of inhibition due to an increase in the IL-1Ra content. The complement system activation occurs along the classical path against the background of an increase in C4 complement component titer. C3a and C5a complement proteolytic fragments are numerously presented in BLV -infected rats, compared to control group animals, which is a marker of an allergic reaction.