Open AccessSynthesis, Characterization and Biological Activity of Two Novel transition metal complexes of pyrazolone
Author(s) -
Yating Chen,
Yipeng Fan,
Jingling Zhang,
Shuhua Zhang
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/639/1/012017
Subject(s) - pyrazolone , pyridine , chemistry , bromide , sodium methoxide , pyrazole , transition metal , ligand (biochemistry) , derivative (finance) , metal , medicinal chemistry , nuclear chemistry , methanol , inorganic chemistry , organic chemistry , catalysis , economics , biochemistry , receptor , financial economics
Using 2-hydrazinopyridine, dimethyl butynedioate and sodium methoxide as raw materials, a new pyridine-pyrazolone derivative containing multiple nitrogen coordination atoms was synthesized through a multi-step reaction, namely the ligand 1-(2-pyridine)-5-hydroxyl -1H-pyrazole-3-carboxylic acid methyl ester (HL). Using solvothermal method, two novel transition metals Co and Zn complexes of pyrazolone were synthesized. The structures were characterized by infrared spectroscopy, XRD and X-ray single crystal diffraction. Notably, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay showed that 2 displayed relatively high cytotoxic activity against Hep-G2 and MGC80-3 cancer cells.