Open AccessStudy of the influence of anthropogenic factors on organism
Author(s) -
С. В. Нотова,
Т. В. Казакова,
О. В. Маршинская,
E. V. Kiyaeva,
Е. В. Шейда
Publication year - 2021
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/624/1/012187
Subject(s) - nanoparticle , toxicity , nanomaterials , iron oxide nanoparticles , spleen , nanotechnology , chemistry , environmental chemistry , materials science , medicine
The use of iron nanoparticles of various forms in industry continues to grow; therefore, there are risks of environmental damage and toxicity. The study was conducted on Wistar rats (n = 36). Nanoparticles of iron oxide and cobalt ferrite were injected once intraperitoneally at doses of 2 and 2.3 mg/kg (45 nm). On the 1st, 7th and 21st day of the experiment, the emotional and motor activities were assessed using the Open Field and Black and White Chamber tests. The results presented demonstrate that the liver and spleen are target organs that are able to accumulate nanoparticles; iron nanoparticles have a neurotropic effect and may have an anxiolytic effect. Despite the negative results obtained, the prospects of using nanoparticles cannot be denied. The use of a systematic and comprehensive approach to the assessment of risks and toxicity of nanomaterials will allow creating conditions to build a unified concept of nanosafety.