Open AccessExposure to traffic-related PM2.5 pollutants significantly affect the diversity and quantity of lung microbiota in a rat model
Author(s) -
WU Xiu-li,
Weiping Zheng,
Song Wen,
Cunya Li,
Xiaoyü Li
Publication year - 2020
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/601/1/012006
Subject(s) - firmicutes , proteobacteria , lung , biology , sphingomonas , bacteroidetes , microbiology and biotechnology , bacteria , medicine , 16s ribosomal rna , genetics
To investigate the microbial alteration of the lung in rats after the traffic-related PM2.5 exposure, thirty female rats had exposed to traffic-related PM2.5 and normal air for 17 days, the microbial changes were identified by Illumina high-throughput sequencing. The pathological structure and the microbial diversity of lungs in exposure groups were significantly changed. The most dominant phylum in lung microbiota changed from Firmicutes to Proteobacteria . Also, Sphingomonas was identified as the key differential bacterium between the exposure and control groups. The results suggest that traffic-related PM2.5 can affect the distribution of lung microbiota and may cause damage of the lung tissues and function.