Open AccessRenoprotective Effects of Lycopene in Tomato Extracts on Rat Exposed to Cadmium
Author(s) -
Hernayanti Hernayanti,
Slamet Santoso,
Sri Lestari,
L. Prayogo,
Kamsinah Kamsinah,
Rochmatino
Publication year - 2020
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/593/1/012005
Subject(s) - lycopene , uric acid , creatinine , chemistry , cadmium , beta 2 microglobulin , antioxidant , metallothionein , renal function , endocrinology , medicine , pharmacology , biochemistry , organic chemistry
Cadmium is a heavy metal widely used in human life. When it enters the body, cadmium might bind to metallothionein protein and impair renal function. The renal function decrease usually is characterized by raise of β2-microglobulin, creatinine, ureum and uric acid levels, which possibly be cured by lycopene, and antioxidant found in tomato. The objective of the study was to determine the effective lycopene dose as a renoprotective of Cd exposure. Twenty four Wistar rats used in this study were divided into six groups (four individuals in each group). Group I was the negative control, Group II was given 5.6 mg/kgBW CdSO4 as a positive control. Group III, IV and V were given 5.6 mg/kgBW CdSO4 and tomato extract of 0.36, 0.72 and 1.08 mg/kgBW/day respectively. Group VI exposed to CdSO4, and after seven days an additional 0.3 mg/kgBW/day of dimercaprol was administered for 14 days as a comparison to tomato. The parameters observed were levels of Cd, creatinine, and β2-microglobulin in blood level. Observations were made on day 0 and day 22. The data were analyzed by ANOVA (F-test), followed by the Duncan test. The results showed that all treatments and dimercaprol could reduce the levels of Cd, creatinine, ureum, uric acid, and β2-Microglobulin. The optimal decrease was observed in the rats administered with 1.08 mg/kgBW/day. Tomato extract dose 1.08 mg/kgBW was the highest in lowering levels of blood Cd, β2-M, creatinine, urea, and uric acid levels.