Open AccessThe impact of the Chimaphila umbellata (L.) W.P. C.Barton extract on the immune response in animals
Author(s) -
Ч Б Кушеев,
E. M. Kutaev,
S. S. Lomboeva,
В. Б. Хобракова,
S. B. Pavlov
Publication year - 2020
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/548/7/072018
Subject(s) - azathioprine , immune system , traditional medicine , antimicrobial , pharmacology , immunosuppression , immunology , positive control , medicine , biology , chemistry , microbiology and biotechnology , disease
With the water-alcohol extraction method was obtained liquid extract from Chimaphila umbellata (L.)W.P.C. Barton . Experimental studies on the azathioprine immunosuppression model showed a pronounced opposition to the development of a secondary immunodeficiency state under the influence of 14-day course use of a dealcoholized extract of the aerial part of Chimaphila umbellata (L.)W. P.C.Barton . The results of the humoral state assessment and cellular link of the immune response in F1 line laboratory mice (C57B1 / 6 × CBA) indicate that the plant extracts: 1. Restores the immune status by the delayed-type hypersensitivity reaction to 85.6%, with 100% in the intact control and 69.9 in the control - azathioprine. 2. Influences the number of antibody-forming cells, significantly increasing their absolute value by 2.36, and the relative - by 1.84 times in comparison with control-azathioprine. The immunocorrecting activity of umbellata wintergreen Chimaphila umbellata (L.) W. P. C.Barton extract is consistent with previously obtained results on the study of antipyretic, analgesic, antimicrobial, and wound healing anti-inflammatory effects.