Open AccessThe Luminescence Mechanism of Glycitein
Author(s) -
Guangjun Li,
Kun Ma
Publication year - 2020
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/546/4/042068
Subject(s) - fluorescence , glycitein , chemistry , luminescence , density functional theory , time dependent density functional theory , biophysics , photochemistry , computational chemistry , materials science , medicine , biology , daidzein , physics , optoelectronics , quantum mechanics , genistein
Amyloid β-peptide is a well-known therapeutic target for Alzheimer’s disease. Many studies have focused on the design and synthesis of effective fluorescent probes. Glycitein has been reported inhibit amyloid-β peptide aggregation, and solution of glycitein alone can give a maximum fluorescence emission at 465nm with excitation at 350nm. Density functional theory (DFT) and time-dependent density functional theory (TDDFT) have been used to interpret the fluorescence luminescence mechanism of glycitein. Glycitein’s fluorescence luminescence mechanism was the intramolecular charge transfer. The result of this study maybe useful to find the further potent fluorescent probes for alzheimer’s early clinical diagnosis.