Open AccessApplication of Tissue Engineering in Skeleton: A Review on Recent Trends and Advances
Author(s) -
Runtian Wang
Publication year - 2020
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/512/1/012175
Subject(s) - tissue engineering , scaffold , cartilage , biochemical engineering , computer science , biomedical engineering , nanotechnology , engineering , biology , materials science , anatomy
Due to the biological properties of bone and cartilage, tissue engineering, a new solution with no limit on supply, has gained much attention and many investigations over the past few years. In this review, three basic elements of tissue engineering in skeleton are discussed. Take planting trees as an analogy, scaffolds are the soil providing support, growth factors are fertilizers and pesticides which create a suitable environment together with scaffolds, and cells are the seed whose health and proliferation are the ultimate goals. Both stem cells and terminal differentiated cells like chondrocytes are investigated. Growth factors promoting differentiation, osteogenesis and vasculation are also included. Moreover, many studies focus on manufacturing scaffolds with perfect biological and mechanical properties, in which various structures and components are researched. Besides, 3D bioprinting are utilized for accurate control. Furthermore, studies on engineering and science, in vivo trials, and more available resources have been researched.