Open AccessEffects of Lycopene on Oxidative Damage and Mitochondrial Function in the Skeletal Muscle of Mice After Strenuous Exercise
Author(s) -
Weiwei Zhang,
Yu Liu
Publication year - 2020
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/512/1/012057
Subject(s) - lycopene , medicine , skeletal muscle , endocrinology , glutathione peroxidase , citrate synthase , malondialdehyde , chemistry , superoxide dismutase , oxidative stress , antioxidant , biochemistry , enzyme
The main purpose of this study is to investigate the effects of lycopene on oxidative damage and mitochondrial function in the skeletal muscle of mice after strenuous exercise. After the establishment of animal models of exercise-induced fatigue, the mice were randomly divided into four groups: quiet control group, exercise fatigue control group, Low-dose lycopene (20mg/kg) + exercise fatigue group, and high dose lycopene (60mg/kg) + exercise fatigue group. After four weeks, the mice were sacrificed and the levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), free calcium-ion (Ca2+), citrate synthase (CS), values of state 3 respiration (S3) and state 4 respiration (S4) were measured. The results show that lycopene could increase the levels of SOD and GPx in muscle, as well as the levels of free calcium-ion, CS, and values of S4 and respiratory control ratio (RCR) in mitochondria, and decrease the MDA levels in muscle. Lycopene has protective effects against strenuous exercise-induced muscle damage and improves mitochondrial function.