Open AccessEarly and Late Initiation Time of Statin Administration Effects on Early and Long-Term Outcome in Acute Coronary Syndrome Patients: A Literature Review
Author(s) -
Maya Qurota A’yun
Publication year - 2020
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/441/1/012196
Subject(s) - acute coronary syndrome , medicine , mace , statin , placebo , intensive care medicine , adverse effect , physical therapy , myocardial infarction , alternative medicine , percutaneous coronary intervention , pathology
Early treatment in acute coronary syndrome plays as key role in short-term and long-term outcome. Some studies showed that statin treatment may improve long-term outcomes in post-ACS patients as secondary prevention. The most effective time to give statin in ACS patients is not well-known. The aim of this study is to review previous studies as to when is the best time to initiate statin therapy to reach the best long-term outcome in patients with ACS. PubMed and Medline database were searched with keywords in search engine. The inclusion criteria were: 1) trials that compared one of the statin drugs to placebo or standard care; 2) follow up at least 30 days; 3) publication between 2000-2018. Total of six studies was collected in this review. Many studies showed that early treatment with statin in patients with ACS in admission is associated with reduced one-year mortality. Moreover, early statin therapy reduced one-year major adverse cardiac effect. Statin therapy should be administered early during hospitalization for ACS on the basic data that early therapy with statin is proven reduced one-year mortality and MACE. Further investigation still needs to specify when is the most effective time to give statin in patient with ACS.