Open AccessPolyazolidinammonium as an adjuvant in immunization with lipopolysaccharide of Yersinia pseudotuberculosis
Author(s) -
В. С. Кузнецова,
Sergey Ivaschenko,
Ivan Domnitsky
Publication year - 2020
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/421/5/052022
Subject(s) - yersinia pseudotuberculosis , adjuvant , lipopolysaccharide , immunization , microbiology and biotechnology , medicine , biology , antibody , immunology , biochemistry , virulence , gene
The use of polyazolidinammonium modified with iodine hydrate ions (PAAG) as an adjuvant made it possible to obtain rabbit hyperimmune serums for the pseudotuberculosis microbe lipopolysaccharide (LPS) with specific specificity. The optimal immunizing dose for obtaining hyperimmune pseudotuberculous sera was a dose of 0.25 mg of LPS Yersinia pseudotuberculosis O:3 serovariant per rabbit. When immunizing rabbits with LPS of the pseudotuberculosis microbe, PAAG showed more pronounced adjuvant properties compared to Freund’s complete adjuvant.