The Effect Of Kelor Leaves (Moringa oleifera) Ethanol Extract On Serum Uric Acid And Tumor Necrosis Factor-α Of Hyperuricemic White Rats (Rattus norvegicus)

Chronic hyperuricemia leads to various complications due to the inflammation and oxidative processes. However, the current chemical medications have caused serious side effects. Ethanol extract of Kelor (Moringga oleifera) leaves contains various active substances potential for decreasing serum uric acid and inflammatory cytokine el. The aim of this experiment is to study the effect of Kelor (Moringga oleifera) leaves ethanol extract to serum uric acid and TNF-α level. The Method used is experimental study with post test only with control group design. Twenty-five white rats were randomly assigned into 5 groups: A (healthy control), B (diseased control; hyperuricaemic), C,D,E (hyperuricemic, given ethanol extract 300,600,1200 mg/KgBW/day). Hyperuricemia inductioan was conducted by administration of 20 g raw cow brain/rat/day for 10 days and was continued until day 17. The result is the average of uric acid (mg/dL) in group A: 4,18±0,55, B: 15,02±0,71, C: 8,46±0,12, D: 6,55±0,14, E: 6,45±0,13. The average of TNF-α (mg/dL) in group A: 29,59±10,67, B: 122,58±40,45, C: 108,80±19,89, D: 60,54±8,40, E: 36,12±8,07. Data analysis used One Way ANOVA, followed by post hoc LSD for uric acid and Kruskall-Wallis, followed by Mann-Whitney tests for TNF-α reveal significant differences among groups. The conclucion of this study is the administration of Kelor (Moringga oleifera) leaves ethanol extract in various doses significantly decrease serum uric acid and TNF-α level of hyperuricemic model white rats.