Open AccessRaman spectroscopy and microstructural characterization of anti-diabetic drug metformin hydrochloride
Author(s) -
F. B. Bayramov,
V. V. Toporov,
Oleg B. Chakchir,
Yury Rud,
A. P. Glinushkin,
B. H. Bairamov
Publication year - 2019
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/390/1/012008
Subject(s) - raman spectroscopy , hydrochloride , metformin , amorphous solid , materials science , drug , metformin hydrochloride , raman scattering , analytical chemistry (journal) , chemistry , nuclear chemistry , organic chemistry , pharmacology , medicine , diabetes mellitus , optics , physics , endocrinology
Results of our high-resolution and high-sensitivity Raman-scattering study of metformin hydrochloride, one of the most frequently used and popular oral anti-diabetic drug which also possesses anti-aging, anti-tumor and anti-inflammatory properties is presented. It is demonstrated that rather narrow (4–10 cm −1 ) spectral lines of molecular vibrations are observed in the metformin hydrochloride pressed powder sample in the important spectral range of 70–1600 cm–1. Thus these “fingerprints” can be used to reveal which chemical bonds produce measurable spectral components corresponding to the vibrations of known particular functional groups and the presence of crystalline state of the metformin hydrochloride without evidence of an amorphous phase. These formulations exhibit considerable advantages and makes the metformin hydrochloride as promising model for novel developments and applications as molecular biosensor in medicine and environmental systems.