Open AccessAcute Oral Toxicity Test of Nicotiana tabacum L. Bio-Oil Against Female Winstar Rats
Author(s) -
Hannah Natasha Andjani,
Yogi Sentosa,
Kori Yati,
Ahmad Fauzantoro,
Misri Gozan,
Young-Choon Yoo
Publication year - 2019
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/353/1/012047
Subject(s) - nicotiana tabacum , toxicity , nicotine , acute toxicity , body weight , biology , toxicology , botany , chemistry , biochemistry , neuroscience , gene , endocrinology , organic chemistry
Tobacco plants are notably known for its pesticidal properties, particularly due to its nicotine content. In this study, Nicotiana tabacum L. bio-oil was obtained using pyrolysis technique. The safety of the bio-oil to be used as bioinsecticide was analyzed through acute oral toxicity test by administering 5000 mg bio-oil/kg body weight of female winstar rats that were analogous to humans. It was concluded that the bio-oil was not toxic due to absence of mortality and no significant change in the body weight and behavior of the rats.