Open AccessProtective Effect of Cajanus cajan in Hepatotoxic Rats
Author(s) -
Evbakhavbokun,
O Okika Winifred,
Iweala E. J. Emeka
Publication year - 2019
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/331/1/012023
Subject(s) - cajanus , alanine aminotransferase , chemistry , body weight , liver injury , albumin , pharmacology , medicine , zoology , biochemistry , biology , agronomy
Hepatotoxicity results from overload of chemicals and drugs including N-Nitrosodiethylamine (NDEA), a nitrosamine found in smoke, meat and food products. This study examined the hepatoprotective potential of Cajanus cajan in male Wistar rats. Hepatotoxicity was induced by administration of NDEA at 200mg/kg while Cajanus cajan was administered at 200mg/kg, 400mg/kg and 800mg/kg for 28 days. Body weight, liver weight and markers of hepatotoxicity including Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Albumin (ALB) were evaluated. NDEA treated group showed a marginal increase in body weight and a significant (p < 0.05) increase in liver weight. The Cajanus cajan treated groups showed a significant (p < 0.05) increase and decrease respectively in body and liver weights. NDEA treated group significantly (P<0.05) increased ALT and AST and significantly reduced ALB. Cajanus cajan significantly (P<0.05) decreased ALT and AST and significantly (P<0.05) elevated ALB. The results indicate that Cajanus cajan ameliorates NDEA-induced hepatotoxicity.