Open AccessBioresorbable polymer matrices impregnated with BMP-2
Author(s) -
С. А. Минаева,
Е. Н. Антонов,
A. V. Vasilyev,
Т. Б. Бухарова,
E V Galitsina,
В. К. Попов
Publication year - 2019
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/320/1/012053
Subject(s) - in vitro , polymer , biocompatibility , saline , chemistry , kinetics , glycolic acid , biomedical engineering , mesenchymal stem cell , sintering , chemical engineering , biophysics , materials science , lactic acid , biochemistry , microbiology and biotechnology , organic chemistry , biology , quantum mechanics , bacteria , medicine , physics , genetics , engineering , endocrinology
Bioresorbable matrices from poly(lactic-co-glycolic acid) containing therapeutically significant concentrations of bone morphogenetic protein 2 (BMP-2) was formed by super-critical fluid encapsulation and surface-selective laser sintering. Biocompatibility of these matrices and the kinetics of BMP-2 release from their volume into physiological saline was investigated. It was shown experimentally that the release of BMP-2 was almost uniform for 15 days. The subsequent use of laser sintering contributed to a longer retention of BMP-2. High cytocompatibility of the obtained matrices with cultures of mesenchymal stem cells was shown in vitro .