Open AccessGenetic diversity of feline leukemia virus
Author(s) -
A.K. Komina,
Alexei D. Zaberezhny,
Oksana D. Kucheruk,
Elena V. Zhukova,
И. А. Гулюкина
Publication year - 2019
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/315/4/042038
Subject(s) - feline leukemia virus , provirus , virology , retrovirus , biology , recombinant dna , virus , endogenous retrovirus , murine leukemia virus , gene , genetics , genome
Feline Leukemia Virus (FeLV) belongs to retrovirus family, causing various proliferative and immunosuppressive diseases in felines. There are two forms of FeLV: endogenous (enFeLV) and exogenous (exFeLV), the latter has 4 subgroups: A, B, C and T with different receptor specificity. The FeLV-A is the most abundant transmissive form. The FeLVB emerged as a recombinant between provirus FeLV-A and endogenous virus of domestic cats. The FeLV-C appeared as a result of accumulation of mutations in the env FeLV-A gene. The chimeric FeLV-T virus was obtaind as recombination event between 61E and 61C viruses. This review also covers two new recently described subgroups - FeLV-D и TG35.