Open AccessEffect of Turmeric Rhizome Extract (Curcuma longa L.) on Kidney Histology of Preeclampsia Rats (Rattus norvegicus L.)
Author(s) -
Syafruddin Ilyas,
Salomo Hutahaean,
Elimasni,
Sayidina Panjaitan
Publication year - 2019
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/305/1/012078
Subject(s) - curcuma , h&e stain , rhizome , kidney , histology , necrosis , preeclampsia , staining , medicine , traditional medicine , andrology , biology , pathology , pregnancy , genetics
Preeclampsia (PE) is second death in pregnancy in Indonesia. This study aims to determine the effect of turmeric extract (Curcuma longa L.) on renal necrosis, narrowing of the proximal tubulus, renal weight and changed of renal color of rats. This study used a type of analytic study with an experimental quasi design in pregnant female rats (Rattus norvegicus) consisting of four treatments with six replications each. The study consisted of a negative control group (K-) with only feed given ad libitum , positive control (K +) in injection of LPS intervena with a dose of 0.2 / kgBW, and 2 group giving turmeric extract (Curcuma longa L.) with doses of 400 mg / kgBW (P1) and 600 mg / kgBW (P2). Rats (Rattus norvegicus) are disectedto take the kidneys. Kidneys are made into a preservative preparation with the paraffin method and staining Hematoxylin-Eosin (HE). The results of renal morphology observations showed a change in color in the treatment group P2. The histological features of the kidneys in the proximal tubulus showed a decrease in P1 compared to the P2 group and the percentage of renal necrosis in P2 had a significant change compared to the positive control group (K+).Extract of Turmericrhizome (Curcuma longa L.) is proven to be able to maintain and improve the structure of cells of the kidneys in the Rats preeclampsia model.