Open AccessEffect of Mahkota Dewa Ethanolic Extracts (Phaleria macrocarpa Scheff.) to Hepar Histology of Female Rat (Rattus novergicus) In Preeclampsia
Author(s) -
Syafruddin Ilyas,
Masitta Tanjung,
Isnaini Nurwahyuni,
Fidayani Pasaribu
Publication year - 2019
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/305/1/012075
Subject(s) - h&e stain , histology , necrosis , staining , biology , hepatocyte , preeclampsia , pathology , andrology , traditional medicine , medicine , pregnancy , biochemistry , genetics , in vitro
Preeclampsia is a disease at 20 weeks’ gestation which is characterized by an abnormal increase in blood pressure (Hypertension) and Proteunaria. This study used a type of analytic study with an experimental quasi design in pregnant female rats (Rattus norvegicus) consisting of four treatments with six replications each. The study consisted of a control group (K) which was only fed ad libitum, Treatment 1 (P1) was injected with LPS intervena at a dose of 0.2 / kgBW, and the group was given extract of Mahkota Dewa Plant (Phaleria macrocarpa Scheff.) With each dose -one of 100 mg / kgBW (P2) and 200 mg / kgBW (P3). Rat liver organ (Rattus norvegicus) is taken after surgery. Liver organ is made into a preservative preparation with paraffin method and staining of Hematoxylin-Eosin (HE). Morphological observations showed a marked decrease in liver weight (p 0.05).