Open AccessThe Effect ofClinacanthus nutans(Burm.f.) Lindau Water Fraction Addition on Hypoglycemia
Author(s) -
Christiana Retnaningsih,
Victoria Kristina Ananingsih,
Meiliana,
Ebta Narasukma Anggraeny,
Intan Martha Cahyani,
Bekti Nugraheni,
Ridwan Efendi
Publication year - 2019
Publication title -
iop conference series. earth and environmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1755-1307
pISSN - 1755-1315
DOI - 10.1088/1755-1315/292/1/012032
Subject(s) - fraction (chemistry) , hypoglycemia , fructose , chemistry , positive control , negative control , zoology , food science , medicine , biology , chromatography , traditional medicine , endocrinology , insulin
This research aimed to investigate the effect of administering water fraction of Clinacanthus nutans [Burm.F.] Lindau (the local name of daun dandang gendis) in different doses on hypoglycemia. The research method was using the test of dandang gendis leaves ( Clinacanthus nutans (Burm.f.) Lindau) water fraction on wistar rats using pre and post test method randomized control group design. The induction using a high-fat diet consisting of pork oil: duck egg (3:1) and fructose 1.8 g/kgBW for 30 days was applied. Rats were divided into 6 groups: normal control (aquadest), negative control (carboxyl methyl cellulose/CMC), positive control (metformin), dose I 15,89 mg/kgBW (water fraction of Clinacanthus nutans [Burm.F.] Lindau), dose II 31,78 mg / kgBW, and dose III 47,67 mg / kgBW. The result showed that a dose of 15,89 mg/kg BW was an effective dose to reduce blood glucose level. of wistar male rats induced by fructose and high-fat feed.