Open AccessEffect of inhaled acetone concentrations on exhaled breath acetone concentrations at rest and during exercise
Author(s) -
Clemens Ager,
Paweł Mochalski,
Julian King,
Chris A. Mayhew,
Karl Unterkofler
Publication year - 2020
Publication title -
journal of breath research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 53
eISSN - 1752-7163
pISSN - 1752-7155
DOI - 10.1088/1752-7163/ab613a
Subject(s) - chemistry , acetone , exhaled air , chromatography , exhaled breath condensate , inhalation , organic chemistry , anesthesia , medicine , toxicology , asthma , biology
Real-time measurements of the differences in inhaled and exhaled, unlabeled and fully deuterated acetone concentration levels, at rest and during exercise, have been conducted using proton transfer reaction mass spectrometry. A novel approach to continuously differentiate between the inhaled and exhaled breath acetone concentration signals is used. This leads to unprecedented fine grained data of inhaled and exhaled concentrations. The experimental results obtained are compared with those predicted using a simple three compartment model that theoretically describes the influence of inhaled concentrations on exhaled breath concentrations for volatile organic compounds with high blood:air partition coefficients, and hence is appropriate for acetone. An agreement between the predicted and observed concentrations is obtained. Our results highlight that the influence of the upper airways cannot be neglected for volatiles with high blood:air partition coefficients, i.e. highly water soluble volatiles.