Three-dimensionally two-photon lithography realized vascular grafts | Zendy

Tania Limongi | Zendy; Laura Brigo | Zendy; Luca Tirinato | Zendy; Francesca Pagliari | Zendy; Alessandro Gandin | Zendy; Paolo Contessotto | Zendy; Andrea Giugni | Zendy; Giovanna Brusatin | Zendy

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Three-dimensionally two-photon lithography realized vascular grafts

Author(s) -

Tania Limongi,

Laura Brigo,

Luca Tirinato,

Francesca Pagliari,

Alessandro Gandin,

Paolo Contessotto,

Andrea Giugni,

Giovanna Brusatin

Publication year - 2020

Publication title -

biomedical materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.744

H-Index - 72

eISSN - 1748-605X

pISSN - 1748-6041

DOI - 10.1088/1748-605x/abca4b

Subject(s) - materials science , lithography , photoresist , vascular graft , biomedical engineering , two photon excitation microscopy , biomaterial , tissue engineering , nanotechnology , capillary action , adhesion , optoelectronics , composite material , optics , medicine , fluorescence , layer (electronics) , physics

Generation of artificial vascular grafts as blood vessel substitutes is a primary challenge in biomaterial and tissue-engineering research. Ideally, these grafts should be able to recapitulate physiological and mechanical properties of natural vessels and guide the assembly of an endothelial cell lining to ensure hemo-compatibility. In this paper, we advance on this challenging task by designing and fabricating 3D vessel analogues by two-photon laser lithography using a synthetic photoresist. These scaffolds guarantee human endothelial cell adhesion and proliferation, and proper elastic behavior to withstand the pressure exerted by blood flow.

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